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北大团队提出基于AlphaFold3的ContactSeek框架实现精准碱基编辑
北京大学伊成器课题组在Nature发表论文，提出基于AlphaFold3接触概率的AI框架ContactSeek。该框架利用AlphaFold3预测的接触概率（CP）捕捉单碱基错配引发的局部构象变化。团队整合CP与高通量脱靶编辑数据，定位影响碱基编辑特异性的关键氨基酸位点，鉴定出可提升ABE精准性的全新Cas9变体。实验证明，这些变体在维持高效在靶编辑的同时降低了DNA脱靶编辑。
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北大团队用AlphaFold3的接触概率设计出更精准的碱基编辑工具，能降低脱靶编辑还不牺牲效率。
2 sources71° AI heatLast updated 2026/7/25 05:17:22
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