这篇论文提出了一个新方法，用神经网络从宏基因组数据预测土壤微生物参数，还能在小样本下保持准确，搞生态模拟或AI交叉的可以看看。
该研究提出了首个混合建模框架，从DNA测序数据推断的宏基因组功能特征中推导过程型土壤有机质周转模型的生物动力学参数值。该框架使用神经网络将基因组性状数据映射到生物动力学参数，并整合生态理论和文献约束以确保行为真实。在合成数据和真实数据上的评估表明，该方法在小训练集条件下仍能有效学习不可观测组分的动态，性能优于多个基线模型。
Constrained hybrid modelling to predict microbial dynamics and organic matter turnover in soil systems
Soil microorganisms control organic matter cycling and largely determine how soil systems can cope with and mitigate climate change and environmental threats. Representing microbial dynamics in process-based soil models is therefore critical to predict carbon cycling in soils, albeit highly challenging to inform from data. One promising approach to improve their parametrisation is the integration of genomic data, yet modelling the complex and unknown relationship between genomes and the processes the microbes are driving is an unsolved problem. In this work, we present the first hybrid modeling framework for deriving biokinetic parameter values of a process-based soil organic matter turnover model from metagenome-inferred functional traits based on DNA sequencing data. Our model predicts biokinetic parameters of the process-based model from genomic trait data with a neural network and integrates constraints from ecological theory and literature to ensure realistic behavior, even of non-observed state variables. We evaluate our method on synthetic genomic trait datasets of varying complexity and on real data, showing that our approach improves performance over multiple baselines and learns the dynamics of unmeasurable components of the process-based model effectively, even for small training datasets.