研究者发布了两个轻量级病理AI模型，GigaPath-Flash在切片分析上几乎不输十亿参数大模型，速度快50倍；GigaTIME-Flash还能直接预测肿瘤微环境，速度更快又省显存。开源可用，做病理和免疫研究很实用。
GigaPath-Flash结合22M参数的ViT-S tile编码器和21M参数的LongNet slide编码器，从十亿参数的GigaPath蒸馏而来，保留97%平均切片级性能但计算量减少50倍。GigaTIME-Flash可直接从H&E图像预测肿瘤免疫微环境，比原版CNN的GigaTIME快6倍、GPU内存少8倍。两个模型均采用Apache-2.0开源许可，权重开放。
GigaPath-Flash and GigaTIME-Flash: Efficient Pathology Foundation Models for Whole-Slide and Tumor Microenvironment Analysis
Foundation models have emerged as a driving force in computational pathology, with the potential to transform cancer diagnosis, prognosis, and treatment selection by learning transferable representations from large-scale histopathology data. A growing landscape of pathology foundation models now spans diverse data sources, architectures, and downstream applications. However, most pretrained models operate only at the image-tile level, use restrictive licenses, and remain computationally expensive, limiting large-scale slide-level clinical and research use. Here, we introduce GigaPath-Flash and GigaTIME-Flash, efficient models for whole-slide pathology AI and spatial proteomics prediction. GigaPath-Flash combines a 22M-parameter ViT-S tile encoder with a 21M-parameter LongNet slide encoder, both pretrained on large-scale real-world histopathology data. Its compact tile encoder is distilled from the billion-parameter GigaPath (ViT-g) teacher and shared by both models. GigaPath-Flash retains 97% of GigaPath's average slide-level performance with 50x less compute. GigaTIME-Flash extends this backbone to predict the tumor immune microenvironment directly from routine H&E images. It surpasses the original CNN-based GigaTIME in prediction quality while running 6x faster and using 8x less GPU memory. Together with GigaPath and GigaTIME, these models form an open-weight, Apache-2.0-licensed family pretrained on large-scale real-world clinical data. By releasing all models and weights, we provide accessible building blocks for computational pathology, immuno-oncology, and precision health.