苹果发布蛋白质序列与结构联合设计模型 SimpleDesign
SimpleDesign: A Joint Model for Protein Sequence and Structure Codesign
苹果搞了个能同时处理蛋白质序列和结构的模型，对做生物信息学或药物研发的朋友可能有用。
苹果开发的 SimpleDesign 模型能同时理解蛋白质的氨基酸序列和三维结构，解决了现有模型依赖多阶段训练的问题。该模型在蛋白质结构预测任务上取得了新进展，为药物发现和蛋白质工程提供了新工具。
SimpleDesign: A Joint Model for Protein Sequence and Structure Codesign
Proteins are fundamental to biological processes, with their function determined by the complex interplay between the amino acid sequence and the three-dimensional structure. Developing generative models capable of understanding this intrinsically multi-modal relationship is crucial for fields like drug discovery and protein engineering. Existing models often rely on a multi-stage training process where autoencoders that tokenize data into latent representations are trained in a first stage. Secondly, a generative model is trained on the latent representation of the autoencoder(s), i.e…
