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Anthropic 生物学发布遭冷思考:新酶系统仅在大肠杆菌中表达验证

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有人泼冷水了:Anthropic 说的这个新酶系统,目前只在大肠杆菌里表达过一次,原理都没搞清,但思路确实有意思。

Anthropic 宣布用模型在生物学数据中发现了一套新的酶系统,但评论者 iScienceLuvr 指出该结果仍处于非常早期的阶段。目前唯一的实验验证只是将该酶系统在大肠杆菌中表达,其工作原理尚不清楚。这条评论认为该发布真正展示的是 LLM 的一种用途:自动化地从生物学数据中挖掘异常发现,用于规模化生成假设。

原文 · Tanishq Abraham (论文推介)

Okay my take on the Anthropic bio announcement:

It's very cool and people should be excited!

but it's also very very very preliminary!

They discovered a new enzyme system but the basically don't know anything about how it works.

The only real lab experiment they've done is just express it in E coli...

Imo this announcement speaks to a broader idea of how LLMs can be used to accelerate biological discoveries: automating the process of finding something unexpected and unusual in biological data to scale up discoveries and hypothesis generation.